abstract：:We studied ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium induced by anthracycline antibiotic daunomycin. A peculiarity of ultrastructural organization of cardiomyocyte nuclei under these conditions is almost complete disappearance of the heteroc...

journal_title：Bulletin of experimental biology and medicine

authors： Nepomnyashchikh LM,Lushnikova EL,Semenov DE

更新日期：2000-12-01 00:00:00

abstract：:Leukocyte count decreased, relative content of neutrophils and monocytes increased, and their phagocytic activity was suppressed in rats with 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced depressive syndrome at the stage of acute behavioral depression. The severity of behavioral depression inversely correlated ...

journal_title：Bulletin of experimental biology and medicine

authors： Krupina NA,Davydova TV,Fomina VG,Kryzhanovskii GN,Orlova IN

更新日期：2000-11-01 00:00:00

abstract：:The influence of a new 2-mercaptobenzimidazole derivative afobazole on cytogenetic effects of dioxidine and cyclophosphamide was studied by counting chromosome aberrations in bone marrow cells of C57Bl/6 mice. Afobazole (1-100 mg/kg perorally) exhibited antimutagenic activity determined by its antioxidant properties. ...

journal_title：Bulletin of experimental biology and medicine

authors： Zhanataev AK,Durnev AD,Seredin SB

更新日期：2000-11-01 00:00:00

abstract：:Activities of enzymes of active oxygen forms detoxication and phase II xenobiotic metabolism were measured in rat hepatoma 27 cells transplanted to different organs. Activity of phase II xenobiotic metabolizing enzymes was higher in hepatoma cells growing subcutaneously than in those transplanted into the liver, while...

journal_title：Bulletin of experimental biology and medicine

authors： Ostashkina NM,Dubovaya TK,Koblyakov VA,Konovalova GG,Lankin VZ

更新日期：2000-11-01 00:00:00

abstract：:One-month therapy with trimetazidine sharply decreased the content of free radical oxidation products, lipid peroxides and malonic dialdehyde, in atherogenic low-density lipoproteins in patients with coronary heart disease. Activity of glutathione peroxidase utilizing lipid peroxides in the plasma markedly increased d...

journal_title：Bulletin of experimental biology and medicine

authors： Tikhaze AK,Lankin VZ,Zharova EA,Kolycheva SV

更新日期：2000-10-01 00:00:00

abstract：:The effects of cerivastatin on antiatherogenic properties of high-density lipoproteins were studied in patients with coronary heart disease and hyperlipidemia. Apart from hypolipidemic effects, cerivastatin changed the phospholipid composition of high-density lipoproteins and improved their cholesterol-acceptor proper...

journal_title：Bulletin of experimental biology and medicine

authors： Ozerova IN,Jeevan DM,Serdyuk AP,Paramonova IV,Akhmedzhanov NM,Metel'skaya VA,Perova NV

更新日期：2000-10-01 00:00:00

abstract：:Formulas for calculation of the section non-perpendicularity error in estimation of the perimeter and cross-sectional area of microvessel profiles are proposed for the two-dimensional isotropic approximation. A relationship was established between the bias and random error associated with non-perpendicularity correspo...

journal_title：Bulletin of experimental biology and medicine

authors： Krasnoperov RA,Grachev SV,Gerasimov AN

更新日期：2000-10-01 00:00:00

abstract：:Experiments on rat model of stress-induced gastric ulcers revealed marked circulatory disturbances in ulcerated gastric mucosa associated with arteriolar spasm and venous congestion and leading to perivascular edema, diapedesis of erythrocytes, and microhemorrhages. These changes were most pronounced on day 1 after ul...

journal_title：Bulletin of experimental biology and medicine

authors： Khadzhiev OC,Lupal'tsov VI,Simonenkov AP,Klimenko NA,Tatarko SV

更新日期：2000-09-01 00:00:00

abstract：:Time course of DNase and RNase activities in the sera of random-bred mice infected with Plasmodium malariae (chloroquine-sensitive strain H) was studied. Similarly to viral infection, infection with a protozoa eukaryotic parasite was accompanied by increased DNAse and RNAse activities, though Plasmodium malariae biolo...

journal_title：Bulletin of experimental biology and medicine

authors： Kovalenko GA,Gal'vita AV

更新日期：2000-09-01 00:00:00

abstract：:hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic ch...

journal_title：Bulletin of experimental biology and medicine

authors： Molodykh OP,Nepomnyashchikh LM,Lushnikova EL,Klinnikova MG

更新日期：2000-09-01 00:00:00

abstract：:Isolation and identification of rat brain protein regulated by serotonin-modulated protein SMP-69 is described. Intracerebral administration of anti-SMP-69 antibodies activates cerebral cortex cell genome and increases the content of electropheretic fraction 28. Intracerebral administration of isolated and purified pr...

journal_title：Bulletin of experimental biology and medicine

authors： Mekhtiev AA

更新日期：2000-08-01 00:00:00

abstract：:Neuroprotective effects of GABA(B) agonist baclofen and GABA(A) agonists THIP and muscimol are completely additive. GABAA and GABA(B) receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effect of two agonists with selective GABA...

journal_title：Bulletin of experimental biology and medicine

authors： Kulinskii VI,Mikhel'son GV

更新日期：2000-08-01 00:00:00

abstract：:The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopami...

journal_title：Bulletin of experimental biology and medicine

authors： Chekhonin VP,Baklaushev VP,Kogan BM,Savchenko EA,Lebedev SV,Man'kovskaya IV,Filatova TS,Yusupova IU,Dmitrieva TB

更新日期：2000-08-01 00:00:00

abstract：:Intranigral administration of glutamate to rats with parkinsonian syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine augmented the development of parkinsonian symptoms (oligokinesia and muscular rigidity), but did not affect motor activity of intact animals. Memantine administered intraperitoneally in pa...

journal_title：Bulletin of experimental biology and medicine

authors： Kucheryanu VG,Kryzhanovskii GN

更新日期：2000-07-01 00:00:00

abstract：:The efficiency of ascorbate and alpha-tocopherol as stabilizers of beta-carotene, which is widely used in complex therapy and prevention of some diseases accompanied by oxidative stress, was studied. The latency of induced beta-carotene oxidation linearly depends on ascorbate concentration, while steady-state rate non...

journal_title：Bulletin of experimental biology and medicine

authors： Kozachenko AI,Gurevich SM,Nagler LG

更新日期：2000-07-01 00:00:00

abstract：:Fifty-six primary neuroendocrine lung tumors were examined morphologically and histologically and their apoptosis level was determined. Malignant carcinomas were characterized by increased apoptotic index and enhanced expression ofBcl-2, Bak, p53, and Ki-67 compared to typical carcinoid. However, apoptosis in these tu...

journal_title：Bulletin of experimental biology and medicine

authors： Pal'tsev MA,Demura SA,Kogan EA,Jaques G,Zende B

更新日期：2000-07-01 00:00:00

abstract：:Cardiac and plasma activities of marker lysosomal enzymes were studied in Wistar rats with metabolic (epinephrine) and occlusion (ligation of coronary arteries) myocardial infarction. Activity of all examined lysosomal enzymes significantly increased in the myocardium and blood plasma starting from the first day after...

journal_title：Bulletin of experimental biology and medicine

authors： Mayanskaya SD,Mayanskaya NN,Efremov AV,Yakobson GS

更新日期：2000-06-01 00:00:00

abstract：:Comparative study on inbred mouse stains showed that in vitro response of T lymphocytes from tuberculosis-susceptible I/St mice to mycobacterial antigens did not differ from that of T lymphocytes from resistant mouse strains. The defect appeared only in the presence of virulent mycobacteria and was not related to T ly...

journal_title：Bulletin of experimental biology and medicine

authors： Radaeva TV,Nikonenko BV

更新日期：2000-06-01 00:00:00

abstract：:The possibility of local laser destruction of the trigeminal sensory root by a puncture technique is demonstrated. A fibrous scar was formed on a limited area of the trigeminal root. There were no signs of axonal regeneration, posttraumatic neuroma, or considerable changes in the Meckel sinus. ...

journal_title：Bulletin of experimental biology and medicine

authors： Giniatullin RU,Kozel' AI,Ismagilova ST

更新日期：2000-06-01 00:00:00

abstract：:Acute experiments on anesthetized rabbits were performed to compare dilator responses of the carotid arteries in a wide range of blood flow rates. In males, the reactivity of vessels to changes in blood flow rate was higher than in females. Thirty percent of the revealed sex differences are due to various blood viscos...

journal_title：Bulletin of experimental biology and medicine

authors： Filatova OV,Kiselev VD,Eismont OV

更新日期：2000-05-01 00:00:00

abstract：:Glutathione S-transferase activity increased in rats with acute pancreatitis: 2.2 times on day 2, 2-fold on day 4, and 1.5 times on day 10. Inducers of microsomal enzymes aroclor 1254 and phenobarbital notably inhibited glutathione S-transferase activity in animals with experimental pancreatitis on days 2-4 of the dis...

journal_title：Bulletin of experimental biology and medicine

authors： Prokop'eva NV,Gulyaeva LF

更新日期：2000-05-01 00:00:00

abstract：:Monoamine metabolism in the hypothalamus and striatum of BALB/c and C57Bl/6 mice (intact and stressed in the open field test) was studied using single- and multidimensional statistical methods. It is suggested that the revealed difference in neurotransmitter metabolism is associated with genetically controlled behavio...

journal_title：Bulletin of experimental biology and medicine

authors： Seredenin SB,Lapitskaya AS,Nadorov SA,Kudrin VS,Badyshtov BA

更新日期：2000-05-01 00:00:00

abstract：:Vagal influences on the heart were studied in narcotized cats, in which the cardiotropic effects of sympathetic nerves, heart rate, and pre- and afterload were excluded. Under these conditions vagus nerve exerted only a positive inotropic effect probably mediated by an unknown humoral factor. ...

journal_title：Bulletin of experimental biology and medicine

authors： Sheikh-Zade YR

更新日期：2000-04-01 00:00:00

abstract：:Pharmacokinetics of GVS-111, a new acylprolyldipeptide with nootropic properties and its penetration across the blood-brain barrier were studied in rats using HPLC. It was found that the dipeptide is absorbed in the gastrointestinal tract, enters the circulation, and penetrates through the blood-brain barrier in an un...

journal_title：Bulletin of experimental biology and medicine

authors： Boiko SS,Ostrovskaya RU,Zherdev VP,Korotkov SA,Gudasheva TA,Voronina TA,Seredenin SB

更新日期：2000-04-01 00:00:00

abstract：:Experiments on male hybrid mice demonstrated that specific immunotherapy with preparations based on carcinoembryonal antigen and mucin containing CA 125 antigen was not associated with general toxicity, local irritating effect, and hepatorenal dysfunction. The absence of toxicity is apparently due to the fact that ant...

journal_title：Bulletin of experimental biology and medicine

authors： Sitdikova SM,Amandzholov BS,Sel'chuk VY,Kormosh NG,Laktionov KP,Lebedin YS,Chukanov SV,Toptygin AY,Manzyuk LV,Donenko FV

更新日期：2000-04-01 00:00:00

abstract：:Preliminary injection of succinic semialdehyde into animals in experiments with hypoxia led to a lower concentration of free ammonia in their brain tissues than in control experiments in which the compound was not given. The enzyme system of the liver tissue catalyzes the oxidation of NAD-H-2 by succinic semialdeyde a...

journal_title：Bulletin of experimental biology and medicine

authors： Zubovskaya AM,Ostrovskaya RU,Tsybina NM

更新日期：1975-01-01 00:00:00

abstract：:Chinese hamster cells in culture were blocked in prometaphase by the addition of chloral hydrate. After 2 h the chloral hydrate was removed and the ultrastructural changes in the kinetochore studied during recovery of mitosis. The kinetochore in the blocked cells is a disc measuring 300-350 nm in diameter and 30-35 nm...

journal_title：Bulletin of experimental biology and medicine

authors： Alov IA,Lyubskii SL

更新日期：1975-01-01 00:00:00

abstract：:The local anaphylactic reaction and the effects of histamine during blocking of the slow sodium-calcium channels by isoptine were investigated in the spontaneously contracting oracle of the atrium of a guinea pig previously sensitized to egg albumin. Simultaneously with the intracellular recording of the potentials, i...

journal_title：Bulletin of experimental biology and medicine

authors： Khodorov BI,Voronovitskii EG,Ignat'eva VB

更新日期：1975-01-01 00:00:00

abstract：:In acute experiments on anesthetized cats activity of sensomotor cortical units was recorded during low-frequency stimulation of the head of the caudate nucleus. Amphetamine (1 mg/kg), although not significantly affecting the spontaneous firing rate, increased the number of spontaneously active cortical units. Meanwhi...

journal_title：Bulletin of experimental biology and medicine

authors： Arushanyan EB,Belozertsev YA,Aivazov KG

更新日期：1975-01-01 00:00:00